Stimulation of prostaglandin biosynthesis by vasoactive substances in methylcholanthrene-transformed mouse BALB/3T3.
نویسندگان
چکیده
منابع مشابه
Evidence that bradykinin stimulates renal prostaglandin synthesis by a mechanism distinct from that of other vasoactive substances.
Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode's solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. To elucidate further the differences in the mechanism of action of BK and other vasoactive age...
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Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention grou...
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Blood pressure is influenced by several vasoactive factors that also regulate nephron transport. An imbalance in regulation of salt reabsorption by the nephron contributes to hypertension. In the spontaneously hypertensive rat (SHR), the responses to dopamine and angiotensin II in the proximal nephron are diminished and enhanced, respectively. This partially explains why the proximal tubule of ...
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Since prostaglandins have been consistently recovered from a wide range of inflammatory reactions, including cutaneous inflammation, we have studied the effect of the anti-inflammatory corticosteroids hydrocortisone and fluocinolone on in-vitro biosynthesis of prostaglandins by skin. Skin homogenates synthesized prostaglandins E(2) and F(2)alpha in the presence of an excess of arachidonic acid ...
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Received October 24, 1978 Summary : Cyclooxygenase catalysis is stimulated by its product, PGG2, and by other lipid hydroperoxides. The endoperoxide, PGH , was not stimulatory. The results provide a direct demonstration of an essen & ial role for lipid hydroperoxides in prostaglandin biosynthesis, and show how the biosynthetic intermediate PGG2 has a positive accelerative effect. INTRODUCTION A...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1976
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)33851-6